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Financial Highlights At December 31, 2016, the Group had cash reserves of US$55.6 million after adjusting for the committed capital of doctor home loan australia Oak Laurel US$21.7 million from the equity purchase agreement with Mallinckrodt Pharmaceuticals announced on December 23, 2016, the proceeds of which were subsequently received on January 6, 2017. During the half-year FY2017, the Company has executed its planned operational streamlining and re-prioritization of projects to successfully absorb the incremental costs of the MPC-150-IM program in advanced chronic heart physician home construction loan Oak Laurel www.oaklaurel.com.au 0430129662 failure (CHF). In line with this objective, operating cash outflows for the half-year FY2017 excluding MPC-150-IM for CHF were reduced by 22% (US$11.5 million) compared with the half-year period ended December 31, 2015 (half-year FY2016). After absorbing the incremental R&D costs associated with the CHF program, total operating cash outflows were US$47.3 million, still a reduction of 9% (US$4.6 million) compared with the half-year FY2016. The US$11.5 million in savings was achieved principally through reduced spend on commercial manufacturing, labor costs within R&D and management & administration. As previously announced, a fully discretionary equity facility has been established for up to $A120 million/$US90 million over 36 months. Key Upcoming Milestones During CY2017, the Company expects to report multiple clinical, regulatory and commercial outcomes. - report on the Phase 3 interim analysis in patients with advanced chronic heart failure (CHF) - report on the Phase 2B top line results for end-stage CHF - release 12 month data on its biologic refractory rheumatoid arthritis (RA) program - complete enrollment in the chronic low back pain (CLBP) Phase 3 trial, and - complete enrollment and read out top-line results in the Phase 3 acute graft versus host disease (aGVHD) trial. The Company expects to report on discussions with the FDA on the potential for certain of its product candidates to be designated as regenerative advanced therapies under the 21 [st] Century Cures Act. Mesoblast intends to enter into strategic alliances with partners who share our corporate vision and can leverage their existing strengths and capabilities to maximize the commercial value of our lead assets. Operational Highlights MPC-150-IM for advanced chronic heart failure (CHF): 1. Mesoblast is currently conducting a Phase 3 trial of MPC-150-IM in New York Heart Association (NYHA) Class II-III advanced CHF patients. This trial's primary endpoint is a comparison of recurrent heart failure-related major adverse cardiovascular events (HF-MACE) in advanced CHF patients receiving either MPC-150-IM by catheter injection into the left ventricular heart muscle or sham control.